Genetic Profile and Secretome of Adipocytes From Visceral and Subcutaneous Adipose Tissue in Patients With Cardiovascular Diseases

Adipose tissue is of interest in the context of its role in pathogenesis of cardiovascular diseases, endothelium and myocardium dysfunction, hypertension, atherosclerosis and a number of other pathological conditions. The accumulation of knowledge about secretory functions of adipocytes is leading to recognition of the role of adipose tissue in regulation of cardiovascular system functioning. Studies of molecular-genetic basis of the functioning of adipose tissue can help to understand etiopathogenetic mechanisms of cardiovascular diseases and develop an effective strategy for their prevention and control. In this review, the information about adipokines and cytokines secreted by various types of adipose tissue (subcutaneous, epicardial, perivascular), as well as changes in the expression of key genes in adipocytes obtained from various fat depots in patients with cardiovascular diseases was analyzed.