Histological evaluation demonstrates a consistent structural pattern across age, sex, and joint sites in normal human synovium, suggesting uniform baseline tissue architecture.
Microscopic study of normal synovial tissue from 16 humans of varying age disclosed an architectural pattern which did not vary significantly with age, sex or intra‐articular location. Except for fibrous synovium, the tissue samples were similar in vascularity, number of surface cell layers and in the differential composition of the surface cells. Histochemical procedures delineated a pericellular surface reticulin network but failed to establish the locus of hyaluronic acid synthesis.
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C. William Castor (1960) studied this question.
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