Production of acid mucopolysaccharides in tissue cultures from human non-inflammatory synovial membranes was studied. The results indicate that hyaluronic acid was the chief acid mucopolysaccharide produced. Hyaluronic acid was synthesized by the synovial as well as by the periarticular tissues. The results did not indicate an appreciable production of (dialysable) hexosamine containing oligosaccharides. Intrinsic viscosity of the acid mucopolysaccharides produced varied from one case to another but kept rather constant from week to week.
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Hedberg et al. (1958) studied this question.