Key result
Recent advances in understanding cardiac myocyte apoptosis highlight the potential for new therapeutic approaches aimed at preventing myocyte loss in ischemic heart disease and congestive heart failure.
This review highlights the evolving understanding of cardiac myocyte apoptosis and its potential as a therapeutic target in cardiovascular diseases.
Recent advances in the understanding of the molecular mechanisms of apoptosis has gained increasing interest in the cardiovascular research community. Apoptotic myocyte loss has been detected in different cardiac disease states such as ischemic heart disease and congestive heart failure. In addition, some evidence for the molecular mechanisms in cardiac myocyte apoptosis has been evolving, although at present the implications thereof for clinical cardiac disease are not known in most of the cases. Based on these new insights, it is the intention of this article to highlight some topics in apoptosis research that might be of particular interest to define the future role and potentials of new therapeutic approaches aimed at preventing myocyte apoptosis.
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Armin Haunstetter (2000) conducted a review in Cardiac disease (ischemic heart disease, congestive heart failure). Therapeutic approaches aimed at preventing myocyte apoptosis was evaluated. Recent advances in understanding cardiac myocyte apoptosis highlight the potential for new therapeutic approaches aimed at preventing myocyte loss in ischemic heart disease and congestive heart failure.
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