Population
Animals and humans with myocardial infarction and heart failure
Design
Review
Authors
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Cautions against targeting cardiomyocyte apoptosis therapeutically; leaves open its true contribution to MI and HF.
Despite indirect evidence of apoptosis in heart disease, direct morphological evidence in cardiomyocytes is lacking, presenting hurdles for clinical application of apoptosis regulation.
Takemura et al. (2006) studied this question.
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