Key result
Cardiomyocyte apoptosis precedes the impairment in ventricular function and its exacerbation accompanies the development of heart failure in patients with hypertensive heart disease.
Cardiomyocyte apoptosis may be a contributing cause of loss and functional abnormalities of cardiomyocytes in hypertensive heart disease, potentially leading to heart failure.
Answers are grounded in this paper and cite their sources.
Apoptosis timing in hypertensive heart disease may inform future targets; leaves open causal role and therapeutic relevance pending prospective trials.
PURPOSE OF REVIEW: It is widely accepted that there are two principal forms of cell death, namely, necrosis and apoptosis. According to the classical view, necrosis is the major mechanism of cardiomyocyte death in cardiac diseases. RECENT DEVELOPMENTS: In the past few years observations have been made showing that cardiomyocyte apoptosis occurs in diverse conditions including hypertensive heart disease, and that apoptosis may be a contributing cause of loss and functional abnormalities of cardiomyocytes in this condition. SUMMARY: This review will summarize recent evidence demonstrating the potential contribution of cardiomyocyte apoptosis to heart failure in hypertensive patients. In addition, some strategies aimed to detect and prevent apoptosis of cardiomyocytes will be considered.
No takes yet. Share an insight, caveat, or question.
González et al. (2006) conducted a review in Hypertensive heart disease. Cardiomyocyte apoptosis precedes the impairment in ventricular function and its exacerbation accompanies the development of heart failure in patients with hypertensive heart disease.
Synapse has enriched 10 related papers. Consider them for comparative context: