May 1, 2000Current Opinion in Cardiology
Apoptosis and cardiomyopathy
Population
Patients with dilated and ischemic cardiomyopathy and end-stage heart failure
Design
Review
Authors
Discussion
Loading...
Member takes
Implication
May contribute to systolic dysfunction in end-stage HF; leaves open whether apoptosis-targeted therapies alter outcomes.
Structured PICO
P
Population
Patients with dilated and ischemic cardiomyopathy and end-stage heart failure (based on studies of endomyocardial biopsies and explanted hearts)
Apoptosis occurs in terminally differentiated adult heart muscle cells during heart failure, which may contribute to systolic dysfunction through the release of cytochrome c and loss of cytoplasmic proteins.
Cite This Study
Narula et al. (2000) studied this question.