Key result
Apoptosis, potentially triggered by regional hypoxia, is proposed as a key mediator of ongoing cardiomyocyte loss and progressive left ventricular dysfunction in heart failure.
Design
Review
Authors
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Apoptosis inhibition untested in HF; leaves open its viability as therapeutic target for trials.
This review highlights cardiomyocyte apoptosis as a potential key mechanism driving heart failure progression, suggesting it as a target for future therapeutic interventions.
Sabbah et al. (1998) conducted a review in Heart failure. Apoptosis (programmed cell death) was evaluated on Progression of left ventricular dysfunction. Apoptosis, potentially triggered by regional hypoxia, is proposed as a key mediator of ongoing cardiomyocyte loss and progressive left ventricular dysfunction in heart failure.
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