Key result
Cardiomyocyte apoptosis, interstitial fibrosis, and inflammatory cell responses are key cytopathological factors driving the progression of left ventricular dysfunction in heart failure.
Population
Patients with heart failure
Design
Review
Authors
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Should not yet change heart failure practice; leaves open whether targeting apoptosis or fibrosis improves outcomes.
This review highlights the roles of cardiomyocyte apoptosis, interstitial fibrosis, and inflammation in the progressive deterioration of left ventricular function in heart failure.
Daniel Petrovič (2004) conducted a review in Heart failure. Cardiomyocyte apoptosis, interstitial fibrosis, and inflammatory cell responses are key cytopathological factors driving the progression of left ventricular dysfunction in heart failure.
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