Key result
Cardiomyocyte apoptosis plays a key role in the development of cardiac diseases, including the transition from hypertensive compensatory hypertrophy to heart failure.
This review highlights the pathophysiological importance of cardiomyocyte apoptosis in hypertensive heart disease and its progression to heart failure.
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May inform apoptosis-targeted therapies in hypertensive heart disease; leaves open clinical relevance pending interventional trials.
The balance between cell death and cell survival is a tightly controlled process, especially in terminally differentiated cells, such as the cardiomyocyte. Accumulating data support a role for cardiomyocyte apoptosis in the development of several cardiac diseases, including the transition from hypertensive compensatory hypertrophy to heart failure. This review briefly summarizes the status of the knowledge regarding the death-survival balance of cardiomyocytes in the context of hypertensive heart disease. Several molecular and cellular aspects as well as the most relevant pathophysiological implications are presented. Moreover, diagnosis tools under development and the possibilities for pharmacological intervention are also examined.
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Fortuño et al. (2003) conducted a review in Hypertensive heart disease. Cardiomyocyte apoptosis plays a key role in the development of cardiac diseases, including the transition from hypertensive compensatory hypertrophy to heart failure.
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