June M. Chan et al. (1) report that plasma insulin-like growth factor–I (IGF-I) was associated with the risk of prostate cancer in a prospective study that paired 152 men with prostate cancer with age-matched healthy men (controls), aged 40 to 82 years at the start of the study. They found that prostate cancer risk increased with concentrations of IGF-I; men with IGF-I values in the highest quartile had 2.4 times [95% confidence intervals (CIs) 1.2 to 4.7] the risk of men in the lowest quartile.
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Schaefer et al. (1998) studied this question.
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