Key result
Pregnancy in women with cardiogenic shock was associated with a lower risk of in-hospital mortality (adjusted OR 0.43) and higher rates of ECMO utilization compared to nonpregnant women.
Why the study?
Cardiogenic shock is associated with high mortality in pregnancy but remains understudied, with unclear etiologies, risk factors, outcomes, and procedural utilization differences.
Observational (n=32,780)
Yes
Odds Ratio: 0.43 (95% CI 0.28–0.66)
Absolute Event Rate: 17.8% vs 29.5%
p-value: p=<0.001
Cardiogenic shock in pregnancy is most commonly caused by peripartum cardiomyopathy and is associated with lower in-hospital mortality but higher ECMO utilization compared to cardiogenic shock in nonpregnant reproductive-aged women.
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Supports heightened ECMO use in pregnant cardiogenic shock but should not change practice; leaves open selection bias versus true survival benefit.
Adebowale et al. (2025) conducted an observational in Cardiogenic shock (n=32,780). Pregnancy vs. Nonpregnant women was evaluated on In-hospital mortality (OR 0.43, 95% CI 0.28-0.66, p=<0.001). Pregnancy in women with cardiogenic shock was associated with a lower risk of in-hospital mortality (adjusted OR 0.43) and higher rates of ECMO utilization compared to nonpregnant women.
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