Starting from 3,6-dichloro-4-pyridazinecarboxylic acid chloride a series of novel pyridazino[3,4- b][1,5]benzoxazepin-5(6 H)-ones as 1,2-diazine isosters of nonnucleoside reverse transcriptase inhibitors was prepared via N-(2-hydroxyphenyl)-3,6-dichloro-4-pyridazinecarboxamides. The inhibition of HIV-1 reverse transcriptase was evaluated.
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Barth et al. (1996) studied this question.
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