Sekundärstoffe aus dem chemischen Screening, 16. Inthomycine, neue Oxazol‐triene aus Streptomyces sp.

Secondary Metabolites by Chemical Screening, 161). – Inthomycins, New Oxazole‐Trienes from Streptomyces sp. The oxazole‐triene metabolites inthomycin A to C (2, 4, 6) have been discovered by chemical screening in the culture broth of Streptomyces sp. (strain Gö 2). Its separation was successful only when the compounds had previously been transformed into the 3‐O‐(S)‐2‐phenylbutanoates 3, 5 and 7. The structures were deduced from their spectroscopic data, especially those taken from 2D‐NMR spectra. The natural products reveal differences in the (E/Z) configuration of its triene chains. By feeding [1‐13C]acetate to growing cultures of strain Gö 2, it was determined that C‐1 to C‐10 of the inthomycins biosynthetically originated via the polyketide pathway. Inthomycin A (2) has already been known as a substructure element of oxazolomycin (1) and probably is identical with the recently described phthoxazolin.