Key result
Non-Newtonian blood viscosity models demonstrated significantly higher local and average viscosity and larger energy loss compared to Newtonian models in pediatric Fontan circulation simulations.
Why the study?
The Fontan circulation presents chronic non-pulsatile low-shear-rate pulmonary blood flow where non-Newtonian blood viscosity effects are likely substantial, but their impact on fluid dynamics and energetic efficiency required evaluation.
Does non-Newtonian blood viscosity modeling affect fluid dynamics and energetic efficiency in computational simulations of pediatric patients with Fontan circulation?
Does non-Newtonian blood viscosity modeling affect fluid dynamics and energetic efficiency in computational simulations of pediatric patients with Fontan circulation?
Non-Newtonian blood behavior significantly contributes to flow structure and energetic inefficiency in computational models of low cardiac output Fontan circulation, highlighting the importance of accurate viscosity modeling.
Answers are grounded in this paper and cite their sources.
Non-Newtonian modeling may refine Fontan CFD accuracy; leaves open clinical translation in pediatric patients.
For univentricular heart patients, the Fontan circulation presents a unique pathophysiology due to chronic non-pulsatile low-shear-rate pulmonary blood flow, where non-Newtonian effects are likely substantial. This study evaluates the influence of non-Newtonian behavior of blood on fluid dynamics and energetic efficiency in pediatric patient-specific models of the Fontan circulation. We used immersed boundary-lattice Boltzmann method simulations to compare Newtonian and non-Newtonian viscosity models. The study included models from twenty patients exhibiting a low cardiac output state (cardiac index of 2 L/min/m2). We quantified metrics of energy loss (indexed power loss and viscous dissipation), non-Newtonian importance factors, and hepatic flow distribution. We observed significant differences in flow structure between Newtonian and non-Newtonian models. Specifically, the non-Newtonian simulations demonstrated significantly higher local and average viscosity, corresponding to a higher non-Newtonian importance factor and larger energy loss. Hepatic flow distribution was also significantly different in a subset of patients. These findings suggest that non-Newtonian behavior contributes to flow structure and energetic inefficiency in the low cardiac output state of the Fontan circulation.
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Wei et al. (2024) studied Fontan circulation (n=20). Non-Newtonian viscosity modeling vs. Newtonian viscosity modeling was evaluated on Metrics of energy loss (indexed power loss and viscous dissipation), non-Newtonian importance factors, and hepatic flow distribution. Non-Newtonian blood viscosity models demonstrated significantly higher local and average viscosity and larger energy loss compared to Newtonian models in pediatric Fontan circulation simulations.
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