Key result
Ventricular-arterial coupling was impaired in Fontan patients at rest and remained significantly impaired compared with healthy controls during peak exercise (0.54 vs 0.32, P=0.001).
Why the study?
Inefficient ventricular-arterial coupling and variable aortopulmonary collateral flow are common in Fontan patients, but their changes during exercise were not characterized.
Does exercise CMR reveal impaired ventricular-arterial coupling and changes in aortopulmonary collateral flow in Fontan patients compared to healthy controls?
Comparison
Fontan patients vs controls during exercise CMR
Design
Cross-sectional exercise CMR study
Authors
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Impaired coupling should not yet guide Fontan management or exercise testing; leaves open its prognostic value and therapeutic relevance.
Observational (n=32)
No
Does exercise CMR reveal impaired ventricular-arterial coupling and changes in aortopulmonary collateral flow in Fontan patients compared to healthy controls?
Absolute Event Rate: 0.54% vs 0.32%
p-value: p=0.001
In Fontan patients, inefficient ventricular-arterial coupling is present at rest and worsens during exercise due to limited contractile reserve, while aortopulmonary collateral flow remains stable and does not increase volume load.
Latus et al. (2022) conducted an observational in Fontan circulation (n=32). Fontan circulation vs. Healthy controls was evaluated on Ventricular-arterial (V-A) coupling (Ea/Ees) at maximum exercise (60 W) (p=0.001). Ventricular-arterial coupling was impaired in Fontan patients at rest and remained significantly impaired compared with healthy controls during peak exercise (0.54 vs 0.32, P=0.001).
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