Key result
Increased pulmonary artery transluminal pressure resulted in a 5-fold increase in wall stress, reaching up to 400 kPa at the bifurcation at 100 mmHg.
Population
Pulmonary arteries of 5 horses unaffected by calcification
Design
Preclinical
Authors
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Elevated wall stress at the equine PA bifurcation may promote calcification; leaves open translation to human pulmonary vascular disease.
High wall stress at the pulmonary artery bifurcation, exacerbated by increased pressure, correlates with regions where calcified lesions typically form in racing horses.
Teeter et al. (2009) studied Arterial calcification (n=5). Increased transluminal pressure vs. Resting pressure was evaluated on Wall stress levels in 4 regions of interest. Increased pulmonary artery transluminal pressure resulted in a 5-fold increase in wall stress, reaching up to 400 kPa at the bifurcation at 100 mmHg.
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