Key result
Frusemide lowers exercise aortic pressure by ~10–15 mmHg but fails to prevent pulmonary hemorrhage.
Why the study?
The effects of intravenous frusemide and phentolamine on pulmonary artery and aortic pressure changes during strenuous exercise in horses were examined to understand their impact on exercise-induced pulmonary hemorrhage.
Population
7 horses undergoing strenuous treadmill exercise
Comparison
Intravenous frusemide vs phentolamine vs control
Design
Experimental study with drug administration before exercise
Authors
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Frusemide does not blunt exercise PAP rises in horses; leaves open its role in EIPH and requires larger confirmatory studies.
Erickson et al. (1992) studied Exercise-induced pulmonary haemorrhage (EIPH) (n=7). Frusemide and phentolamine vs. Control was evaluated on Mean pulmonary artery pressure (PAP) and mean aortic pressure (AP). Frusemide decreased mean aortic pressure by 10 to 15 mmHg during exercise but did not prevent haemorrhaging, and phentolamine did not sufficiently reduce pressures to test the EIPH hypothesis.
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