Key result
Bidirectional changes in cortical temperature profoundly modulated sensory-evoked neural and vascular responses in a non-linear manner, with cooling delaying neurovascular coupling and heating inducing low-frequency oscillations.
Why the study?
Much remains unknown regarding neurovascular coupling in health and disease, and the interplay between neurovascular coupling and brain thermodynamics has only recently begun to be recognized.
Does bidirectional modulation of cortical temperature alter spatiotemporal neurovascular responses in a rat model?
Does bidirectional modulation of cortical temperature alter spatiotemporal neurovascular responses in a rat model?
Bidirectional modulation of brain temperature profoundly alters neurovascular coupling in a non-linear manner, providing critical insights into brain thermodynamics and the interpretation of functional neuroimaging.
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May confound neurovascular imaging interpretations; leaves open human translation of non-linear effects.
Boorman et al. (2023) studied Healthy (Neurovascular coupling) (n=6). Bidirectional cortical temperature modulation vs. Normothermia (~37°C) was evaluated on Sensory-evoked neural and hemodynamic responses (LFP, MUA, Hbt). Bidirectional changes in cortical temperature profoundly modulated sensory-evoked neural and vascular responses in a non-linear manner, with cooling delaying neurovascular coupling and heating inducing low-frequency oscillations.
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