300mg of γ-oryzanol per day was administered to 17 hyperlipemic patients with or without diabetes daily for 16 weeks. Serum lipids (cholesterol, triglyceride, phospholipid, HDL-cholesterol, cholesterylester, β-lipoprotein, lipid peroxide) were analysed every 4 weeks. Both serum cholesterol and β-lipoprotein were decreased in 8 or 16 weeks. HDL-cholesterol was slightly increased, but lipid peroxide level was unchanged. Serum triglyceride level was very variable. There was no side effect but one bothered with skin eruption.
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OHSAWA et al. (1983) studied this question.
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