What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Atherosclerosis (n=1253). Intervention: Age and cardiovascular risk factors (systolic blood pressure, serum cholesterol). Primary outcome: Surface involvement (SI) and atherosclerotic index (AI) of atherosclerotic lesions in aortas and coronary arteries.

What question did this study set out to answer?

To characterize the natural history and progression of atherosclerosis in infants, children, and young adults and evaluate the relationship between adult coronary heart disease risk factors and arterial lesion extent.

January 1, 2000The Journal of Japan Atherosclerosis SocietyOpen Access

The progression of atherosclerotic lesions in infants, children and young adults in Japan; the pathological co-operative study in the multi centers

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Key result

Atherosclerotic lesions in the aorta and coronary arteries increased with age, with aortic surface involvement significantly correlating with serum cholesterol and age, and coronary involvement correlating with systolic blood pressure.

Population

Autopsied Japanese infants, children, and young adults aged 1 month to 39 years.

Design

Cross-sectional

Authors

MIMasami ImakitaGeneral Medical Council CYChikao YutaniSaiseikaisenri Hospital ASAkinobu SumiyoshiUniversity of Miyazaki

Discussion

Member takes

Implication

Progression of lesions in young Japanese males over 13 years warrants attention; extends prior correlations but remains hypothesis-generating.

Key Points

To characterize the natural history and progression of atherosclerosis in infants, children, and young adults and evaluate the relationship between adult coronary heart disease risk factors and arterial lesion extent.
Multicenter pathological autopsy study across six major laboratories in Japan examining 945 aortas and 976 coronary arteries from subjects aged 1 month to 39 years.
Arteries were stained with Sudan IV and evaluated for fatty streaks, fibrous plaques, and complicated lesions using point counting to calculate surface involvement (SI) and atherosclerotic index (AI).
Histological metrics were correlated with cardiovascular risk factors and compared with historical autopsy cohort data collected 13 years prior.
Aortic surface involvement was greatest in the abdominal aorta for all age groups over 1 year, with mean SI and AI across aortas and coronary arteries increasing progressively with age in both sexes.
Young adult males in their third and fourth decades exhibited significantly higher coronary artery SI and AI compared to historical cohorts and other demographic groups.
Systolic blood pressure significantly correlated with coronary SI and AI as well as aortic AI, while serum cholesterol and age significantly correlated with aortic SI in stepwise multiple regression.

Study Design

Type

Cross-Sectional (n=1,253)

Multicenter

Yes

Structured PICO

Population

1,253 autopsied infants, children, and young adults aged 1 month to 39 years in Japan, evaluated for the progression of atherosclerotic lesions in the aorta and coronary arteries.

Outcome

Prevalence and extent of atherosclerotic lesions measured by surface involvement (SI) and atherosclerotic index (AI) in aortas and coronary arteries.surrogate

Atherosclerotic lesions in the coronary arteries of young Japanese males have progressed compared to 13 years prior, and are significantly correlated with age, systolic blood pressure, and serum cholesterol.

Limitations

Retrospective study design prevented sufficient analysis of risk factors
Need for future prospective studies incorporating molecular biology techniques
Retrospective study design limited the sufficient analysis of risk factors

Cite This Study

Imakita et al. (2000) conducted a cross-sectional in Atherosclerosis (n=1,253). Age and cardiovascular risk factors (systolic blood pressure, serum cholesterol) was evaluated on Surface involvement (SI) and atherosclerotic index (AI) of atherosclerotic lesions in aortas and coronary arteries. Atherosclerotic lesions in the aorta and coronary arteries increased with age, with aortic surface involvement significantly correlating with serum cholesterol and age, and coronary involvement correlating with systolic blood pressure.

synapsesocial.com/papers/6a97d9bb44220fce7874bf66 https://doi.org/10.5551/jat1973.27.7-8_213

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Implication

Progression of lesions in young Japanese males over 13 years warrants attention; extends prior correlations but remains hypothesis-generating.

The progression of atherosclerotic lesions in infants, children and young adults in Japan; the pathological co-operative study in the multi centers

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Limitations

Cite This Study

The progression of atherosclerotic lesions in infants, children and young adults in Japan; the pathological co-operative study in the multi centers

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider