Key result
Older age, male gender, and cardiovascular cause of death were significantly associated with greater aortic intima thickness and severity of atherosclerosis in 141 autopsied patients.
Population
141 aorta samples from autopsied patients (ranging from young adults to the elderly)
Design
Cross-sectional
Authors
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Autopsy associations warrant no practice change; leaves open prospective validation of intima thickness as atherosclerosis marker.
Cross-Sectional (n=141)
Detailed morphological analysis of the aorta, including layer thickness and mast cell infiltration, provides a sensitive evaluation of atherosclerosis severity beyond macroscopic assessment.
Ferraz et al. (2012) conducted a cross-sectional in Atherosclerosis (n=141). Demographic and clinical factors (age, gender, race, cause of death) was evaluated on Macroscopic degree of atherosclerosis, thickness of intima and media, lipid and collagen depositions, and mast cell infiltration. Older age, male gender, and cardiovascular cause of death were significantly associated with greater aortic intima thickness and severity of atherosclerosis in 141 autopsied patients.
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