Key result
Aortic and subclavian atherosclerosis are linked to CAD at autopsy, unlike carotid atherosclerosis.
Why the study?
The relationship between the intensity of atherosclerosis, coronary artery disease, and atherosclerotic risk factors had not been completely revealed by autopsy studies.
Cross-Sectional (n=100)
No
p-value: p=<0.001
Atherosclerosis in the thoracic aorta, abdominal aorta, and subclavian artery, but not the carotid artery, is a significant indicator of coronary artery disease in autopsy cases.
Aortic/subclavian atherosclerosis was associated with CAD at autopsy; leaves open whether targeted vascular imaging aids CAD detection in living patients.
Objective: Atherosclerosis is a generalized, chronic disease of large and medium-sized muscular elastic arteries. Relation between intensity of atherosclerosis and coronary artery disease, and risk factors of atherosclerosis could not been revealed completely by autopsy studies. We aimed to renew this shortage of knowledge with our autopsy study prospectively. Methods: One hundred cases were autopsied within 48 h after death. Atherosclerotic risk factor data were collected including age, gender, height, weight, smoking and any chronic coronary artery disease. Atherosclerosis severity was evaluated macroscopically by examining the inner surfaces of the vascular lumens and revealed with postmortem pathological findings of coronary artery disease. Results: The mean age was 42 ± 22 years. Seventy-four percent of cases were male, while 26% were female. Smoking duration ranged from 1 to 50 years with a mean duration of 17 ± 12 years. Existence of atherosclerosis in main vessels were also in correlation with age, duration of smoking and BMI (Body Mass Index) (p
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Yurtsever et al. (2023) conducted a cross-sectional in Coronary Artery Disease and Atherosclerosis (n=100). Atherosclerosis in main arteries vs. Lack of atherosclerosis was evaluated on Correlation between coronary artery disease and atherosclerosis in the thoracic aorta (p=<0.001). Atherosclerosis in the thoracic aorta, abdominal aorta, and subclavian artery was significantly correlated with the presence of coronary artery disease at autopsy, whereas carotid artery atherosclerosis was not.
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