Key result
Autopsy assessment of 49 cases revealed that the majority of atherosclerotic lesions were grade 4 (59.1%) or grade 3 (38.7%), with the left anterior descending artery showing the most occlusion.
Why the study?
Ischemic heart disease following atherosclerosis is a leading cause of death among Indians, motivating assessment and grading of histomorphological atherosclerotic changes in coronaries and aorta at autopsy using Modified AHA Classification.
Observational (n=49)
No
In an Indian autopsy cohort, the majority of atherosclerotic lesions in coronary arteries were classified as Modified AHA grade 4, with the left anterior descending artery being the most frequently occluded.
Indicates high prevalence of advanced coronary lesions in Indian autopsies; leaves open applicability to clinical risk stratification.
Ischemic heart disease following atherosclerosis is a leading cause of deaths among Indians. The study was formulated to assess the Histomorphological atherosclerotic changes in coronaries and aorta in autopsy by applying Modified American Heart Association Classification (AHA) among the autopsy cases received at SIMS & RC, Bangalore. 1. To evaluate the autopsies for atherosclerosis in coronary arteries and aorta. 2. To classify atherosclerosis in coronary arteries (right coronary, left coronary, left anterior descending) and aorta by Modified American Heart Association classification (Grade 1-8). Autopsy was studied for 49 cases from June 2019 to August 2019. It was conducted by conventional method and heart was dissected along the flow of blood. Grossly macro-assessment was done and on histopathology examination microscopic assessment was done using Modified American Heart Association Classification. A total of 49 cases were studied, of which 42 cases were male and 7 were females. Male to female ratio was around 6:1. Coronary showing major occlusion was Left Anterior Descending followed by Right Coronary and then Left Circumflex artery. Major number of cases were belonging to grade 4 (59.1%) followed by in grade 3 (38.7%). Calcification was noted in 6 cases (12.2%) and ruptured plaque in 4 (8.16%). With the cardiovascular diseases attaining pandemic proportions, the study of atherosclerosis and its grading is the need of hour to estimate disease burden. Autopsy studies play a vital role in unraveling the spectrum and occurrence of atherosclerosis.
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Harveen et al. (2022) conducted an observational in Atherosclerosis (n=49). Autopsy assessment of atherosclerosis was evaluated on Atherosclerosis grade by Modified American Heart Association classification. Autopsy assessment of 49 cases revealed that the majority of atherosclerotic lesions were grade 4 (59.1%) or grade 3 (38.7%), with the left anterior descending artery showing the most occlusion.
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