Psychopharmacotherapy of Schizophrenia with Long-Acting Antipsychotic Drugs in the Context of Expansion of Hospital-Substituting Forms of Psychiatric Care

Background: the main goals of schizophrenia spectrum disorders therapy include not only achieving clinical improvement, but also the restoration of social functioning. This is especially relevant in light of the biopsychosocial concept of the development of this disease, which necessitates an integrated approach to considering its etiopathogenetic and therapeutic aspects. The main treatment and rehabilitation work with patients at the current stage of development of practical healthcare is carried out on an outpatient basis. This is facilitated by the reform of the psychiatric service with the reduction of the inpatient unit and the development of inpatient-substituting forms of mental health care. The aim of review was to analyze the scientific publications on the development of psychiatric care for schizophrenia spectrum disorders in outpatient settings. Material and Methods: using keywords “schizophrenia”, “outpatient care”, “long acting injectable antipsychotics” the source of articles on the possibilities of using long-acting antipsychotic drugs to improve compliance with the therapeutic regimen and prevent psychotic relapse was carried out in PUBMED, e-library and other bases for 10 years. The positive and negative aspects of the use of deposited dosage forms at the stage of maintenance antipsychotic therapy are considered. Additional psychosocial therapies are discussed as part of an integrated approach to treating patients with schizophrenia. Conclusion: the results of the review allow us to conclude that there is a need to develop pharmacological and psychosocial treatment of schizophrenia at the outpatient stage, with an emphasis on anti-relapse maintenance therapy and concomitant social rehabilitation.