What question did this study set out to answer?

To evaluate the in situ antioxidant capacity and photoprotective activity of a topical dermo-cosmetic cream containing three active antioxidants in skin exposed to UVA radiation.

July 16, 2019Experimental DermatologyOpen Access

In situ antioxidant activity of a dermo‐cosmetic product: A randomized controlled clinical study

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Authors

VRVirginie Ribet VNVincenzo Nobile ARAna B. Rossi

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Overview

Randomized double-blind trial shows a topical triple-antioxidant cream reduces UVA-induced oxidative damage in healthy volunteers, highlighting its photoprotective efficacy.

Key Points

To evaluate the in situ antioxidant capacity and photoprotective activity of a topical dermo-cosmetic cream containing three active antioxidants in skin exposed to UVA radiation.
Conducted a monocentric, randomized, double-blind, vehicle- and active-controlled intra-individual study in 20 healthy volunteers over a 30-day period.
Assigned defined skin sites to receive daily applications of the triple-antioxidant cream (pre-tocopheryl, retinaldehyde, and glycylglycine ole-amide), its vehicle, or a positive antioxidant control cream.
Exposed treated areas to controlled UVA radiation, collecting stratum corneum samples by tape stripping to measure antioxidant capacity via ferric reducing ability of plasma and lipid peroxidation via malonyldialdehyde assay at 4 and 24 hours post-irradiation on days 0, 15, and 30.
The antioxidant cream significantly increased stratum corneum antioxidant capacity after 15 and 30 days compared with vehicle and untreated controls.
Basal lipid peroxidation levels, as well as post-UVA lipid peroxidation at 4 and 24 hours, were significantly reduced at days 15 and 30.
Observed protective effects were significantly superior to vehicle and untreated sites while matching the performance of the active positive control.

Cite This Study

Ribet et al. (2019) studied this question.

synapsesocial.com/papers/6a92ded76cd82e562097bad3 https://doi.org/10.1111/exd.14005

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July 16, 2019Experimental DermatologyOpen Access

In situ antioxidant activity of a dermo‐cosmetic product: A randomized controlled clinical study

View Full Paper

Ask AI

Bookmark

Authors

VRVirginie Ribet VNVincenzo Nobile ARAna B. Rossi

Discussion

Member takes

Overview

Randomized double-blind trial shows a topical triple-antioxidant cream reduces UVA-induced oxidative damage in healthy volunteers, highlighting its photoprotective efficacy.

Key Points

To evaluate the in situ antioxidant capacity and photoprotective activity of a topical dermo-cosmetic cream containing three active antioxidants in skin exposed to UVA radiation.
Conducted a monocentric, randomized, double-blind, vehicle- and active-controlled intra-individual study in 20 healthy volunteers over a 30-day period.
Assigned defined skin sites to receive daily applications of the triple-antioxidant cream (pre-tocopheryl, retinaldehyde, and glycylglycine ole-amide), its vehicle, or a positive antioxidant control cream.
Exposed treated areas to controlled UVA radiation, collecting stratum corneum samples by tape stripping to measure antioxidant capacity via ferric reducing ability of plasma and lipid peroxidation via malonyldialdehyde assay at 4 and 24 hours post-irradiation on days 0, 15, and 30.
The antioxidant cream significantly increased stratum corneum antioxidant capacity after 15 and 30 days compared with vehicle and untreated controls.
Basal lipid peroxidation levels, as well as post-UVA lipid peroxidation at 4 and 24 hours, were significantly reduced at days 15 and 30.
Observed protective effects were significantly superior to vehicle and untreated sites while matching the performance of the active positive control.

Cite This Study

Ribet et al. (2019) studied this question.

synapsesocial.com/papers/6a92ded76cd82e562097bad3 https://doi.org/10.1111/exd.14005

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