Population
Cultured renal proximal tubular cells from two different species (MCT and LLC-PK1 cells)
Comparison
Angiotensin II with or without various… vs Control conditions
Design
Preclinical
Authors
Loading...
p44/42 MAP kinase inhibition may attenuate AngII-driven tubular hypertrophy; leaves open translation to human hypertensive kidney disease.
Angiotensin II-mediated oxidative stress induces p27Kip1 expression and hypertrophy in proximal tubular cells through the essential activation of p44/42 MAP kinase.
Hannken et al. (2000) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: