Key result
Bilateral renal denervation significantly restored sodium and water excretion and GFR in stroke-prone spontaneously hypertensive rats subjected to aortic clamping.
Why the study?
Does bilateral renal denervation restore sodium and water excretion and GFR in stroke-prone spontaneously hypertensive rats subjected to acute normalization of renal perfusion pressure?
Population
Stroke-prone spontaneously hypertensive rats (SHRSP)
Comparison
Bilateral renal denervation vs SHRSP with aortic clamping without denervation…
Design
Preclinical
Authors
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Preclinical support for renal sympathetic role in hypertensive renal impairment; hypothesis-generating and should not change practice.
Does bilateral renal denervation restore sodium and water excretion and GFR in stroke-prone spontaneously hypertensive rats subjected to acute normalization of renal perfusion pressure?
Renal sympathetic nerve activity plays a significant role in the reduced water and sodium excretion observed in stroke-prone spontaneously hypertensive rats.
Nagaoka et al. (1982) studied Stroke-prone spontaneously hypertensive rats (SHRSP). Bilateral renal denervation vs. Aortic clamping without denervation / sympatholytic drugs was evaluated on Sodium and water excretion and GFR. Bilateral renal denervation significantly restored sodium and water excretion and GFR in stroke-prone spontaneously hypertensive rats subjected to aortic clamping.
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