Population
Spontaneously hypertensive rats and normotensive control rats anesthetized with pentobarbital sodium
Comparison
Severance of right and left splanchnic nerves… vs Normotensive control rats undergoing the…
Design
Preclinical
Authors
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Supports heightened splanchnic sympathetic tone in hypertensive models; hypothesis-generating for human neuromodulation.
Spontaneously hypertensive rats demonstrate elevated sympathetic tone, as higher stimulation frequencies are required to restore arterial pressure after splanchnic nerve severance compared to normotensive controls.
Juro Iriuchijima (1973) studied this question.
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