Key result
Spontaneous renal nerve activity was elevated in spontaneously hypertensive rats, and excitatory stimulation elicited larger adrenal nerve responses compared to normotensive rats.
Population
12- to 14-wk-old spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKY)
Comparison
Spinal transection at C1 followed by graded… vs Normotensive Wistar-Kyoto rats undergoing the…
Design
Preclinical
Authors
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Spinal mechanisms may contribute to sympathetic hyperactivity in hypertension models; extends mechanistic insights but leaves open human translation.
Spinal and/or ganglionic mechanisms may generate a component of the sympathetic hyperactivity and adrenomedullary hyperexcitability exhibited by spontaneously hypertensive rats.
Schramm et al. (1982) studied Spontaneous hypertension. Spontaneously hypertensive rats (SHR) vs. Normotensive Wistar-Kyoto rats (WKY) was evaluated on Integrated renal nerve activity and adrenal nerve activity. Spontaneous renal nerve activity was elevated in spontaneously hypertensive rats, and excitatory stimulation elicited larger adrenal nerve responses compared to normotensive rats.
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