Why the study?
Does graded splanchnic nerve stimulation elicit different cardiovascular reactivity in spontaneously hypertensive rats compared to normotensive controls?
Population
Adult spontaneously hypertensive rats (SHR) and normotensive controls (NCR)
Comparison
Graded splanchnic nerve stimulation vs Normotensive controls undergoing the same…
Design
Preclinical
Authors
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Altered sympathetic capacitance responses in SHR may sustain hypertension; leaves open relevance to human disease mechanisms.
Does graded splanchnic nerve stimulation elicit different cardiovascular reactivity in spontaneously hypertensive rats compared to normotensive controls?
In established hypertension, elevated resistance may be maintained by normal sympathetic discharge, but accentuated discharge to the capacitance side is needed to maintain proper cardiac filling of the hypertrophied left ventricle.
Noresson et al. (1979) studied this question.
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