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September 5, 2012The LaryngoscopeOpen Access

Outcome of per oral wide excision of T1‐2 N0 localized squamous cell cancer of the buccal mucosa—analysis of 156 cases

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Authors

AHArsheed Hussain HakeemSPSultan PradhanJTJagadish Tubachi

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Overview

Retrospective study reveals favorable survival following peroral wide excision in early buccal cancer, indicating elective neck dissection may be reserved primarily for stage T2 tumors.

Key Points

  • To evaluate oncologic outcomes and recurrence patterns in patients undergoing peroral wide excision for early localized T1–2 N0 squamous cell carcinoma of the buccal mucosa.
  • Retrospective analysis of 156 patients with clinical stage T1–2 N0 buccal mucosa squamous cell carcinoma treated with peroral wide excision at a tertiary-care hospital.
  • Patients were monitored over a median follow-up duration of 48 months to assess local control, regional recurrence, and survival.
  • Across 156 patients, 3-year overall survival was 91.7% and disease-free survival was 70.5%, with 110 patients (70.5%) remaining free of recurrence.
  • Recurrences occurred in 42 patients (78% within 2 years), with regional nodal metastasis significantly higher in stage T2 (15/70 [21.4%]) than stage T1 (9/86 [10.5%]; P=0.032).
  • Successful salvage was achieved in 93.3% (14/15) of local recurrences and 100% (24/24) of regional metastases, whereas 0 of 3 locoregional recurrences could be salvaged.

Cite This Study

Hakeem et al. (2012) studied this question.

synapsesocial.com/papers/6a92e0669da65ccb784a2a0dhttps://doi.org/10.1002/lary.23707
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Also Consider

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  1. 1Analysis of epidemiological and clinicopathological risk factors for locoregional recurrence of oral cavity squamous cell carcinoma: retrospective analysis of 150 patients with buccal mucosal carcinoma in a tertiary care centre2024
  2. 2Comparison of oncologic effectiveness of transoral approach and en bloc resection for pT3 squamous cell carcinoma of the tongue and floor of the mouth2026
  3. 3Efficacy of neoadjuvant immunochemotherapy followed by surgery in locally advanced buccal squamous cell carcinoma: A single-center real-world study.2026
  4. 4Neck Dissection Reduces Risk of Recurrence in Early‐Stage Oral Tongue Cancer2025
  5. 5Sentinel lymph node biopsy experience in squamous cell carcinoma of the oral mucosa сT1–2N0M02024