Key result
Subtotal removal of a clival region mass in a 58-year-old woman led to the rare diagnosis of epithelioid hemangioendothelioma based on histopathologic and immunohistochemical features.
Case Report (n=1)
This case report highlights the rare occurrence of epithelioid hemangioendothelioma in the clival region, emphasizing the role of histopathology and immunohistochemistry in definitive diagnosis.
Supports considering epithelioid hemangioendothelioma in clival mass differentials; extends the anatomic spectrum of this rare tumor.
Epithelioid hemangioendothelioma (EHE) is a rare and low-grade vascular tumor, which usually occurs in the soft tissue, liver, breast, lung and skeleton. Here we submit a case with EHE of the clival region. A 58-year-old woman was admitted with a medical history of 3 months headache and 1 month visual deterioration. MRI revealed a well-circumscribed mass of 4.0 cm × 3.0 cm with bony invasion. The tumor was subtotally removed in a piecemeal fashion. Histologically, the tumor was composed of epithelioid cells with eosinophilic cytoplasm and intracytoplasmic vacuoles. Immunohistochemically, the tumor cells were positive for the markers CD31, CD34, factor VIII and vimentin. The pathological result was interpretated as EHE of the clival region. EHE is an uncommon vascular tumor, which is rarely seen in the clival region. Definitive diagnosis depends on histopathologic and immunohistochemical features.
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Ma et al. (2010) conducted a case report in Epithelioid hemangioendothelioma (EHE) of the clival region (n=1). Subtotal tumor removal was evaluated on Pathological and immunohistochemical diagnosis. Subtotal removal of a clival region mass in a 58-year-old woman led to the rare diagnosis of epithelioid hemangioendothelioma based on histopathologic and immunohistochemical features.
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