Key result
In Swiss large white pigs, body weight strongly correlated with aortic valve diameter (r = 0.83) and area (r = 0.84), but not with coronary ostia heights or aorto-mitral angle size.
Why the study?
Understanding porcine cardiac dimensions via three-dimensional CT can increase preclinical study success, cost efficiency, and observance of the 3 R principles for evaluating prosthetic valves and transcatheter techniques.
Cross-Sectional (n=24)
No
Effect estimate: r = 0.83
p-value: p=<0.0001
In Swiss large white pigs, body weight correlates with several valvular dimensions but not with coronary ostia height or aorto-mitral angle, indicating that body weight alone is insufficient for selecting appropriately sized animals for testing specific cardiac implants.
Body weight alone may not suffice for porcine model selection; leaves open multi-parameter criteria for cardiac implant studies.
The pig (Sus Scrofa Domestica) is an accepted model for preclinical evaluation of prosthetic heart valves and trans-catheter implantation techniques. Understanding porcine cardiac dimensions through three-dimensional computed tomography (CT), increases preclinical study success, leading to higher cost efficiency and to the observance of the obligation to the 3 R principles. Cardiac CT images of twenty-four Swiss large white pigs were segmented; aortic root, mitral valve, pulmonary trunk, tricuspid valve, as well as the aorto-mitral angle and left atrial height were analyzed. Correlation coefficient (r) was calculated in relation to body weight. In Swiss large white pigs, valvular dimensions, length of the pulmonary artery and ascending aorta as well as left atrial height correlate with body weight. Coronary ostia heights and aorto-mitral angle size can be neglected in animal size selection; no changes were found for either of the two parameters with increasing body weight.
No takes yet. Share an insight, caveat, or question.
Lipiski et al. (2020) conducted a cross-sectional in Healthy domestic pigs (preclinical model) (n=24). Body weight was evaluated on Correlation between body weight and aortic valve diameter (r = 0.83, p=<0.0001). In Swiss large white pigs, body weight strongly correlated with aortic valve diameter (r = 0.83) and area (r = 0.84), but not with coronary ostia heights or aorto-mitral angle size.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: