Key result
A door-to-TIMI-3 flow time of 121-330 minutes (quartile 4) was associated with a significantly increased risk of myocardial damage compared to shorter times, with an adjusted odds ratio of 7.0.
Why the study?
Does a shorter door-to-TIMI-3 flow time reduce myocardial damage in patients with acute myocardial infarction?
Population
100 patients with acute myocardial infarction presenting within 12 hours of symptom onset with ST-segment…
Comparison
Shorter door-to-TIMI-3 flow time, specifically… vs Longer door-to-TIMI-3 flow time, specifically…
Design
Cohort
Follow-up
30 days
Authors
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Supports faster door-to-TIMI-3 flow in AMI to limit damage; hypothesis-generating for time targets pending RCTs.
Observational (n=100)
No
Does a shorter door-to-TIMI-3 flow time reduce myocardial damage in patients with acute myocardial infarction?
Odds Ratio: 7 (95% CI 1.4–36)
A door-to-TIMI-3 flow time of less than 55 minutes is associated with significantly reduced myocardial damage in patients with acute myocardial infarction undergoing reperfusion therapy.
Watanabe et al. (2004) conducted an observational in Acute Myocardial Infarction (n=100). Door-to-TIMI-3 flow time vs. Shorter door-to-TIMI-3 flow time was evaluated on Myocardial damage (peak CK >3,000 U/L) (OR 7.0, 95% CI 1.4-36.0). A door-to-TIMI-3 flow time of 121-330 minutes (quartile 4) was associated with a significantly increased risk of myocardial damage compared to shorter times, with an adjusted odds ratio of 7.0.
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