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The following characteristic changes of self-reproduction, growth and differentiation of CFU surviving 300 R60 Co irradiation in vivo were found: (1) CFU duplication from IBM started 24 hr earlier than from CBM; (2) Colonies from ICFU showed a more rapid growth at the beginning than colonies from control CFU; and (3) The ratio of erythroid: granuloid (E:G) colonies decreased and more megakaryocytic colonies were found in the IBM-transplanted group. The change in the E:G ratio proved to be transient. The more rapid growth of colonies and the earlier start of CFU duplication may be explained by the heterogeneity of the pluripotential CFU population. The possible selection of a more radioresistant CFU fraction is suggested.
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Gidáli et al. (1972) studied this question.
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