Key result
The matrix protein of vesicular stomatitis virus inhibits bidirectional nucleocytoplasmic transport by interacting with nuclear pore complexes from within the nucleus, a process dependent on methionine 51.
Population
Xenopus laevis oocytes and transfected HeLa cells
Comparison
Vesicular stomatitis virus matrix protein and… vs Control oocytes (no M protein) or non-specific IgG
Design
Preclinical
Authors
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No immediate clinical implications for viral therapies; hypothesis-generating for methionine 51-dependent transport mechanisms.
The VSV M protein inhibits nucleocytoplasmic transport by interacting with NPCs from within the nucleus, a process dependent on methionine 51.
Petersen et al. (2000) studied Vesicular Stomatitis Virus (VSV) infection mechanism. Vesicular Stomatitis Virus (VSV) Matrix (M) protein vs. Control oocytes / mutant M proteins was evaluated on Inhibition of bidirectional nucleocytoplasmic transport. The matrix protein of vesicular stomatitis virus inhibits bidirectional nucleocytoplasmic transport by interacting with nuclear pore complexes from within the nucleus, a process dependent on methionine 51.
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