Key result
Viral culture-positive cerebrospinal fluid samples contained significantly higher echovirus genome copy numbers than culture-negative samples (329 vs 34.2 copies/μL), demonstrating the high sensitivity of q-RT-PCR which detected echovirus in all 40 cases.
Why the study?
Does q-RT-PCR improve the detection of echovirus in the CSF of aseptic meningitis patients compared to viral culture?
Cross-Sectional (n=40)
No
Does q-RT-PCR improve the detection of echovirus in the CSF of aseptic meningitis patients compared to viral culture?
Absolute Event Rate: 329% vs 34.2%
p-value: p=<0.05
q-RT-PCR is highly sensitive for detecting echovirus in the CSF of aseptic meningitis patients, successfully identifying the virus even in culture-negative samples.
No takes yet. Share an insight, caveat, or question.
q-RT-PCR may enhance echovirus detection in aseptic meningitis CSF; hypothesis-generating and should not yet change practice.
Fujimoto et al. (2009) conducted a cross-sectional in Aseptic meningitis (n=40). Viral culture-positive status vs. Viral culture-negative status was evaluated on Echovirus genome copy numbers in cerebrospinal fluid (copies/μL) (p=<0.05). Viral culture-positive cerebrospinal fluid samples contained significantly higher echovirus genome copy numbers than culture-negative samples (329 vs 34.2 copies/μL), demonstrating the high sensitivity of q-RT-PCR which detected echovirus in all 40 cases.
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