Key result
Transcatheter aortic valve implantation improved the von Willebrand factor large multimer index from 68.3% to 129.7% and prevented recurrence of gastrointestinal bleeding over 3 years of follow-up.
Case Report (n=1)
No
TAVI for severe aortic stenosis in a patient with Heyde's syndrome improved high-molecular-weight von Willebrand factor levels and prevented recurrence of gastrointestinal bleeding.
Heyde's syndrome is a disease in which patients with aortic stenosis (AS) bleed from angiodysplasia. An 80-year-old woman with a history of severe AS was referred to our hospital with melena and anemia. The patient underwent jejunal resection after repeated blood transfusions. A pathological examination revealed angiodysplasia, and the patient's plasma lacked high-molecular-weight von Willebrand factor (VWF) multimers, leading to the diagnosis of Heyde's syndrome. The patient underwent transcatheter aortic valve implantation (TAVI) one year after the diagnosis, and the VWF index recovered. This is a valuable case in which the pathological analysis of angiodysplasia associated with Heyde's syndrome was possible.
No takes yet. Share an insight, caveat, or question.
Kubo et al. (2022) conducted a case report in Heyde's syndrome (Aortic stenosis and GI bleeding from angiodysplasia) (n=1). Transcatheter aortic valve implantation (TAVI) was evaluated on Improvement of VWF large multimer index and resolution of GI bleeding. Transcatheter aortic valve implantation improved the von Willebrand factor large multimer index from 68.3% to 129.7% and prevented recurrence of gastrointestinal bleeding over 3 years of follow-up.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: