Key result
Deletion of glycoprotein gI from the rescued Bartha strain of pseudorabies virus strongly affects virus release and decreases plaque size on rabbit kidney cells.
Population
Rabbit kidney cells infected with pseudorabies virus (wild-type and Bartha vaccine strain)
Comparison
Deletions introduced into the viral genomes… vs Wild-type virus and 'rescued' Bartha strain
Design
Preclinical
Authors
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gI effects on PRV release appear strain-dependent; leaves open essentiality in wild-type viruses or other models.
Glycoprotein gI affects pseudorabies virus release from infected cells, but its essential role is only unmasked in the Bartha strain where another viral function is defective.
Mettenleiter et al. (1987) studied Pseudorabies virus infection. Deletion of gI and/or gp63 genes vs. Wild-type virus and rescued Bartha strain was evaluated on Virus release and plaque size on rabbit kidney cells. Deletion of glycoprotein gI from the rescued Bartha strain of pseudorabies virus strongly affects virus release and decreases plaque size on rabbit kidney cells.
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