Serial sections from 1 block of either a normal or hyperplastic prostate demonstrated at least 2 foci of perineural invasion in 7 of 8 consecutive autopsies. In addition to the perineural invasion a close relationship was found among nerves, glandular epithelium and vascular structures in all 8 autopsies. Although there are differences between the epithelium in perineural invasion in carcinoma and in normal or hyperplastic prostates perineural invasion can no longer be regarded as unequivocal evidence of malignancy.
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Per Henrik Becher Carstens (1980) studied this question.
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