Key result
The Zucker Diabetic Sprague Dawley (ZDSD) rat model features intact leptin signaling and slow onset of diabetes, obesity, and dyslipidemia to mimic the development of diabetic cardiomyopathy.
May facilitate preclinical diabetic cardiomyopathy research; leaves open translation to clinical practice.
Introduction: Diabetic Cardiomyopathy (DC) is the leading cause of morbidity and mortality among all complications of Type 2 Diabetes (T2D) and obese patients. It is characterized by an initial cardiac hypertrophy followed by declines in cardiac functions, which ultimately leads to heart failure. No rodent models fully captured phenotypes of DC. The Zucker Diabetic Sprague Dawley (ZDSD) rat, a new generation of T2D rat model with intact leptin signaling features with slow onset of diabetes, obesity and dyslipidemia, which closely mimics the development of the disease in patients. Here we sought to evaluate the cardiac function during the development of metabolic syndromes in ZDSD rats.
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Sun et al. (2018) studied Diabetic Cardiomyopathy. Zucker Diabetic Sprague Dawley (ZDSD) rat model was evaluated on Cardiac function during the development of metabolic syndromes. The Zucker Diabetic Sprague Dawley (ZDSD) rat model features intact leptin signaling and slow onset of diabetes, obesity, and dyslipidemia to mimic the development of diabetic cardiomyopathy.
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