Key result
Antibody neutralization tests measured higher plasma levels of coagulation factors II, VII, IX, and X compared to specific assays in patients receiving phenindione therapy.
Why the study?
Do antibody neutralization tests yield higher measured levels of factors II, VII, IX, and X compared to specific assays in patients receiving phenindione therapy?
Do antibody neutralization tests yield higher measured levels of factors II, VII, IX, and X compared to specific assays in patients receiving phenindione therapy?
Antibody neutralization tests yield higher measured levels of vitamin K-dependent coagulation factors than specific assays in patients on phenindione.
May overestimate factor levels by antibody neutralization in phenindione patients; leaves open optimal assay choice for monitoring.
Summary. The levels of factors II (prothrombin), VII, IX and X in the plasma of patients on anticoagulant therapy with phenindione have been shown to be higher by antibody neutralization tests than by specific assays.
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K. W. E. Denson (1971) studied this question. Antibody neutralization tests measured higher plasma levels of coagulation factors II, VII, IX, and X compared to specific assays in patients receiving phenindione therapy.
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