Key result
Amiodarone can cause rare but potentially life-threatening diffuse alveolar haemorrhage, which in this 73-year-old patient resolved after drug discontinuation and high-dose steroid therapy.
Why the study?
Amiodarone is commonly used but can rarely cause diffuse alveolar haemorrhage, a potentially life-threatening complication.
Can amiodarone cause acute diffuse alveolar haemorrhage in patients treated for atrial fibrillation?
Case Report (n=1)
No
Can amiodarone cause acute diffuse alveolar haemorrhage in patients treated for atrial fibrillation?
Amiodarone can rarely cause acute, life-threatening diffuse alveolar haemorrhage that requires immediate drug cessation and corticosteroid treatment.
May prompt consideration of amiodarone in unexplained alveolar haemorrhage; leaves open incidence and risk factors in AF.
Amiodarone is an antiarrhythmic agent that is used commonly in clinical practice. It is associated with many side effects, the most common being pulmonary manifestations. Interstitial pneumonitis is one of the most common complications, however rarely amiodarone can cause diffuse alveolar haemorrhage (DAH) too. We describe the case of a 73-year-old woman who presented with shortness of breath and haemoptysis 4 days after starting amiodarone. She was diagnosed with amiodarone-induced DAH based on imaging and bronchoalveolar lavage. She was treated with intravenous and then oral steroids, and amiodarone was discontinued. The patient made a significant clinical and radiological recovery. She was discharged 10 days after her presentation. This case highlights a rare but potentially life-threatening complication of a commonly used medication.
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Saeed et al. (2019) conducted a case report in Amiodarone-induced diffuse alveolar haemorrhage (n=1). Amiodarone was evaluated on Diffuse alveolar haemorrhage. Amiodarone can cause rare but potentially life-threatening diffuse alveolar haemorrhage, which in this 73-year-old patient resolved after drug discontinuation and high-dose steroid therapy.
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