Key result
The myoM(-) mutation did not affect Dictyostelium growth or development, while GFP-tagged MyoM accumulated at crown-shaped projections and vesicles, suggesting a role in macropinocytosis.
Population
Dictyostelium cells
Design
Preclinical
Authors
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MyoM localization implicates it in macropinocytosis; leaves open its necessity and requires mammalian validation.
The identification of a novel unconventional myosin (MyoM) with a RhoGEF domain in Dictyostelium suggests a potential role in macropinocytosis.
Oishi et al. (2000) studied this question. myoM(-) mutation and GFP-tagged MyoM was evaluated on Growth, terminal developmental phenotype, and cellular localization. The myoM(-) mutation did not affect Dictyostelium growth or development, while GFP-tagged MyoM accumulated at crown-shaped projections and vesicles, suggesting a role in macropinocytosis.
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