Key result
Ginsenoside Rg3 treatment in a rat model of diabetic nephropathy reversed the expression of 28 genes, predominantly those involved in fatty acid metabolism and PPAR signaling pathways.
Why the study?
Does ginsenoside Rg3 alter gene expression profiles in a rat model of diabetic nephropathy?
Population
6 male Sprague-Dawley rats. Diabetic nephropathy induced by high lipid diet for two months followed by…
Comparison
Ginsenoside-Rg3 administered once a day for 30… vs Diabetic nephropathy control group and normal…
Design
Preclinical, Rats were divided randomly into three groups
Follow-up
30 days
Authors
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Ginsenoside Rg3 may modulate lipid metabolism in diabetic nephropathy models; leaves open human translation and efficacy trials.
Does ginsenoside Rg3 alter gene expression profiles in a rat model of diabetic nephropathy?
Ginsenoside Rg3 alters gene expression related to lipid metabolism and PPAR signaling in a rat model of diabetic nephropathy, suggesting potential molecular mechanisms for its therapeutic effect.
Wang et al. (2016) studied Diabetic nephropathy (n=6). Ginsenoside Rg3 vs. Diabetic nephropathy control group was evaluated on Differentially expressed genes. Ginsenoside Rg3 treatment in a rat model of diabetic nephropathy reversed the expression of 28 genes, predominantly those involved in fatty acid metabolism and PPAR signaling pathways.
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