Integrative study reveals divergent cellular, microbial, and transcriptomic dynamics between regeneration and larval development in sponges, highlighting distinct mechanisms for body remodeling.
species during remodeling process. Transcriptomics revealed distinct signatures: regeneration upregulated genes potentially related to DNA repair and dedifferentiation but downregulated stem cell markers. Our integrative study indicates that regeneration and development constitute distinct processes, achieving similar functional outcomes via divergent cellular, microbial, and molecular profiles that provides a foundational framework for future mechanistic studies of regeneration.
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Jia et al. (2026) studied this question.
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