Key result
Co-differentiating human embryonic stem cells with mouse stem cells accelerated human developmental programs, with 929 genes upregulated earlier than in human cell cultures alone.
Population
Human embryonic stem cells
Comparison
Co-differentiation with mouse pluripotent stem… vs Human cell cultures alone
Design
Preclinical
Follow-up
six weeks
Authors
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Accelerates human stem cell timelines in co-culture; leaves open whether interspecies signals can enhance maturation for cardiovascular regeneration.
Co-differentiating human embryonic stem cells with mouse stem cells accelerates human developmental programs, suggesting that species-specific developmental clocks can be modified.
Thompson et al. (1969) studied Stem cell differentiation. Co-differentiation with mouse pluripotent stem cells vs. Human cell cultures alone was evaluated on Gene expression profiles (upregulation and peaked expression). Co-differentiating human embryonic stem cells with mouse stem cells accelerated human developmental programs, with 929 genes upregulated earlier than in human cell cultures alone.
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