Key result
This review summarizes the molecular pathways mediating the pathological activation and differentiation of valvular interstitial cells in the development of calcific aortic stenosis.
Why the study?
The molecular mechanisms underlying valvular interstitial cell activation and differentiation into osteoblast- and myofibroblast-like cells in calcific aortic stenosis are not fully understood.
This review summarizes current knowledge on the molecular pathways driving valvular interstitial cell activation and differentiation in calcific aortic stenosis.
Answers are grounded in this paper and cite their sources.
Advances molecular insights into calcific aortic stenosis; leaves open targeted validation and therapeutic translation.
Calcific aortic stenosis is the most common valvular heart disease. The pathogenesis of this disease is complex and resembles the atherosclerotic process in the blood vessels. It is known that valvular interstitial cell activation and subsequent differentiation into osteoblast- and myofibroblast-like cells is the main driving force of fibrous and calcified aortic valve tissue. However, the molecular mechanisms behind these processes are still not fully understood. Current information on this issue is collected and analyzed in this article. The main molecular pathways mediating the pathological differentiation of the valvular interstitial cells and the reasons for their activation are considered.
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A. E. Kostyunin (2019) conducted a review in Calcific aortic stenosis. This review summarizes the molecular pathways mediating the pathological activation and differentiation of valvular interstitial cells in the development of calcific aortic stenosis.
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