Key result
The TC genotype at position 96121524 of the ERAP-1 gene was associated with an increased risk of preeclampsia (OR 2.002; 95% CI 0.687-5.831; P=0.020).
Why the study?
To explore the correlation of polymorphisms of endoplasmic reticulum aminopeptidase-1 (ERAP-1) gene in Chinese women with preeclampsia.
Is the ERAP-1 gene polymorphism associated with an increased risk of preeclampsia in Chinese women?
Case-Control (n=99)
No
Is the ERAP-1 gene polymorphism associated with an increased risk of preeclampsia in Chinese women?
The ERAP-1 gene polymorphism at position 96121524 may be associated with increased susceptibility to preeclampsia in Chinese women of Han nationality.
Answers are grounded in this paper and cite their sources.
May support ERAP-1 as preeclampsia susceptibility marker in Han Chinese; hypothesis-generating and requires prospective validation.
Objective To explore the correlation of polymorphisms of endoplasmic reticulum aminopeptidase-1 (ERAP-1) gene in Chinese women with preeclampsia.Method In this case–control study, 51 severely preeclamptic and 48 healthy pregnant women were retrospectively involved in Beijing Obstetrics and Gynecology Hospital from October 2017 to October 2019. The venous blood and umbilical cord blood were collected to analyze different single nucleotide polymorphisms (SNPs) in ERAP-1 gene in both groups.Result We firstly screened nine SNPs that were significantly different between two groups (P< .1) via univariate analysis. Pearson Chi-Square Test and Fisher’s Exact Test were performed to verify the correlation of SNPs with preeclampsia. Finally, genotype TC located in 96121524 position was associated with an increased risk of preeclampsia (P= .020, OR = 2.002, 95% CI: 0.687–5.831).Conclusion There might be a correlation between polymorphism of 96121524 in ERAP-1 gene and preeclampsia susceptibility in pregnant women of Han nationality in Beijing.
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Ma et al. (2021) conducted a case-control in Preeclampsia (n=99). ERAP-1 gene polymorphisms (genotype TC at position 96121524) vs. Healthy pregnant women / absence of genotype was evaluated on Risk of preeclampsia (OR 2.002, 95% CI 0.687-5.831, p=0.020). The TC genotype at position 96121524 of the ERAP-1 gene was associated with an increased risk of preeclampsia (OR 2.002; 95% CI 0.687-5.831; P=0.020).
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